neurofibrillary tangles

How are Neurofibrillary Tangles Related to Alzheimer's Disease?

NFTs are one of the hallmark pathologies of Alzheimer's disease, along with amyloid plaques. In Alzheimer's, tau proteins detach from microtubules and stick together to form tangled clumps inside neurons. The presence of NFTs in the brain correlates with the severity of dementia and cognitive decline. Understanding the formation and progression of NFTs can help in developing targeted therapies for Alzheimer's disease.

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