Neuroborreliosis is most commonly reported in the northern hemisphere, particularly in regions like North America and Europe. In the United States, it is more prevalent in the Northeast and Upper Midwest. The incidence rate varies, but it is estimated that between 10% to 15% of Lyme disease cases progress to neuroborreliosis. Seasonal variations are also observed, with higher incidence rates in the spring and summer months when tick activity is at its peak.
