How are PROMIS instruments developed and validated?
PROMIS instruments are developed through a multi-step process that includes item generation, item calibration, and validation.
1. Item Generation: Items are generated based on literature reviews, expert consultations, and patient input to ensure they are relevant and comprehensive. 2. Item Calibration: Items are tested on large, diverse samples to calibrate them using Item Response Theory (IRT). This ensures that the items are sensitive across different levels of the health domain being measured. 3. Validation: The instruments undergo rigorous validation studies to confirm their reliability and validity. This includes testing for internal consistency, test-retest reliability, and construct validity.
