Yes, p-values can be misleading if not interpreted correctly. They can lead to overemphasis on statistical significance while neglecting practical significance. For instance, a small p-value might be obtained in a study with a large sample size, even if the observed effect is trivial. Conversely, a large p-value might result from a study with a small sample size, even if the effect is substantial. Therefore, it is crucial to consider the p-value in conjunction with other statistical measures and the broader context of the research.