1. Diagnosis and Classification: They help in diagnosing diseases accurately and classifying them according to their histological characteristics. 2. Etiological Studies: By analyzing tissue samples, researchers can identify causative agents, such as bacteria, viruses, or environmental toxins. 3. Public Health Surveillance: Tissue samples can be used to monitor the spread of diseases and the emergence of new pathogens. 4. Biomarker Identification: They are pivotal in discovering biomarkers that can predict disease onset, progression, or response to treatment.