The use of antifungal prophylaxis comes with both potential benefits and risks.
Benefits: - Reduced incidence of invasive fungal infections: This is the primary benefit, leading to lower [mortality rates](href). - Shorter hospital stays: Prevention of infections can result in reduced hospital admissions and length of stay. - Cost-effectiveness: Prophylaxis can be more cost-effective compared to treating established infections.
Risks: - Drug resistance: Prolonged use of antifungals can lead to the development of resistant fungal strains. - Adverse drug reactions: These can range from mild (nausea, vomiting) to severe (hepatotoxicity, QT prolongation). - Drug interactions: Many antifungals interact with other medications, complicating treatment regimens.
