epigenome wide association studies

What are the key methodologies used in EWAS?


EWAS typically involve several key steps:
Sample Collection and Preparation: Biological samples such as blood, tissue, or saliva are collected and processed to extract DNA.
Epigenetic Profiling: Techniques such as bisulfite sequencing or microarrays are used to measure DNA methylation levels across the genome.
Statistical Analysis: Advanced statistical methods are used to identify significant associations between epigenetic marks and the phenotypes of interest.
Validation: Findings are often validated using independent cohorts or additional experimental techniques.

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