Sample Collection and Preparation: Biological samples such as blood, tissue, or saliva are collected and processed to extract DNA. Epigenetic Profiling: Techniques such as bisulfite sequencing or microarrays are used to measure DNA methylation levels across the genome. Statistical Analysis: Advanced statistical methods are used to identify significant associations between epigenetic marks and the phenotypes of interest. Validation: Findings are often validated using independent cohorts or additional experimental techniques.