What are the Mechanisms of HCA-Induced Carcinogenesis?
HCAs can induce cancer through several mechanisms. Once ingested, these compounds undergo metabolic activation in the liver, producing reactive metabolites. These metabolites can bind to DNA, forming DNA adducts, which, if not repaired, can lead to mutations and initiate carcinogenesis. Additionally, HCAs can induce oxidative stress and inflammation, further contributing to cancer development.