While antitoxins are highly effective in neutralizing toxins, they have some limitations: - Allergic Reactions: Since many antitoxins are derived from animal sera, there is a risk of allergic reactions in humans. - Limited Availability: Some antitoxins may not be readily available, especially in resource-limited settings. - Short Duration of Action: Antitoxins provide passive immunity, which is temporary. They do not induce long-term immunity, so additional measures, such as vaccination, are necessary for long-term protection. - Specificity: Antitoxins are highly specific to the toxin they are designed to neutralize and are ineffective against other toxins.