When applying the ERI model in epidemiological research, several methodological considerations must be addressed. First, accurate measurement of effort, reward, and overcommitment is essential. Standardized questionnaires, such as the ERI Questionnaire developed by Siegrist, are commonly used. Second, longitudinal studies are particularly valuable as they can demonstrate causal relationships between ERI and health outcomes. Finally, controlling for confounding variables like age, gender, and socioeconomic status is crucial to ensure the validity of the findings.