How Do Researchers Address Confounders in Vaccine Efficacy Studies?
Confounders are variables that can distort the true relationship between the vaccine and the disease outcome. Researchers use several methods to address confounders:
Randomization: Allocating participants randomly to groups to balance confounders. Stratification: Analyzing results within subgroups defined by confounders. Multivariable Analysis: Statistical techniques to adjust for multiple confounders simultaneously.