Nosocomial infections spread through various routes: - Direct Contact: Physical interaction between an infected individual and a susceptible host. - Indirect Contact: Interaction via a contaminated intermediate object or surface. - Droplet Transmission: Spread through respiratory droplets during coughing or sneezing. - Airborne Transmission: Dissemination of pathogens through the air over longer distances. - Vector-borne Transmission: Carried by vectors such as insects.