How Do Genetic Polymorphisms Affect CYP450 Activity?
Genetic polymorphisms in CYP450 genes can result in four types of metabolizers:
1. Poor Metabolizers (PM): Little to no enzyme activity, leading to higher drug levels and increased risk of adverse effects. 2. Intermediate Metabolizers (IM): Reduced enzyme activity, resulting in moderate drug levels. 3. Extensive Metabolizers (EM): Normal enzyme activity, leading to standard drug metabolism. 4. Ultra-rapid Metabolizers (UM): Increased enzyme activity, leading to lower drug levels and potentially reduced efficacy.