cyp450

How Do Genetic Polymorphisms Affect CYP450 Activity?

Genetic polymorphisms in CYP450 genes can result in four types of metabolizers:
1. Poor Metabolizers (PM): Little to no enzyme activity, leading to higher drug levels and increased risk of adverse effects.
2. Intermediate Metabolizers (IM): Reduced enzyme activity, resulting in moderate drug levels.
3. Extensive Metabolizers (EM): Normal enzyme activity, leading to standard drug metabolism.
4. Ultra-rapid Metabolizers (UM): Increased enzyme activity, leading to lower drug levels and potentially reduced efficacy.

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