Understanding CYP450 is vital for epidemiologists for several reasons:
1. Drug Metabolism: Variations in CYP450 enzyme activity can influence drug efficacy and toxicity. This has implications for population-level studies on drug response and adverse drug reactions. 2. Genetic Polymorphisms: Genetic variations in CYP450 genes can lead to differences in enzyme activity among individuals and populations. Studying these polymorphisms helps in understanding susceptibility to various diseases and responses to treatment. 3. Environmental Exposures: CYP450 enzymes metabolize many environmental toxins. Differences in enzyme activity can affect how populations are impacted by environmental exposures.
