Several factors make the CNS particularly challenging for epidemiologists:
Complexity of Symptoms: CNS diseases often present with a wide range of symptoms that can overlap with other conditions, making diagnosis difficult. Variable Progression: The progression of CNS diseases can vary significantly among individuals, complicating the study of their natural history and outcomes. Genetic and Environmental Interactions: Both genetic predispositions and environmental factors play a role in CNS diseases, necessitating multifaceted research approaches.