Multi-center studies are crucial for several reasons: 1. Increased Sample Size: Pooling data from multiple centers increases the sample size, improving the precision and reliability of the study results. 2. Diverse Populations: They allow for the inclusion of participants from different geographical areas and backgrounds, which enhances the external validity of the findings. 3. Resource Sharing: Collaboration among multiple institutions allows for the sharing of resources, expertise, and workload, making large-scale studies more feasible.