Data Standardization: They provide a standardized method for data collection, ensuring that all relevant information is captured uniformly across all study sites. Data Quality: CRFs help in maintaining high data quality by minimizing errors and inconsistencies. Regulatory Compliance: Properly designed CRFs ensure compliance with regulatory requirements, which is essential for study approval and validation. Data Analysis: The structured data collected through CRFs facilitate easier and more accurate analysis, interpretation, and reporting of study results.