What Role Does Distribution Play in Pharmacokinetics?
Once absorbed, drugs are distributed throughout the body. Distribution is influenced by factors such as blood flow, tissue permeability, and the drug's affinity for different tissues. Epidemiologically, distribution studies can reveal disparities in drug efficacy and safety among different populations. For example, a drug that distributes widely into fat tissues might have prolonged effects in obese individuals compared to those with lower body fat percentages.
