APCs are fundamental to the mechanism of action of most vaccines. Vaccines often contain weakened or inactivated pathogens, or specific antigens, that are recognized by APCs. Once these antigens are presented to T-cells, a memory response is generated, providing long-term protection against the pathogen. Enhancing the interaction between APCs and T-cells can potentially improve vaccine efficacy, making it a significant area of research in immunology and public health.
