The widespread use of INSTIs has had a profound impact on HIV epidemiology. By achieving rapid viral suppression, INSTIs help reduce the viral load in patients, thereby decreasing the risk of HIV transmission. This contributes to the overall goal of reducing the incidence of new HIV infections. Moreover, the improved efficacy and tolerability of INSTIs have led to better adherence to ART regimens, enhancing treatment outcomes and reducing the burden on healthcare systems.