Profuse watery diarrhea can be caused by various pathogens, including bacteria, viruses, and parasites. Common bacterial causes include Vibrio cholerae, which causes cholera, and certain strains of Escherichia coli, such as ETEC (Enterotoxigenic E. coli). Viral causes include rotavirus and norovirus, while parasitic causes include Giardia lamblia and Cryptosporidium. These pathogens disrupt the normal absorption of water and electrolytes in the intestines, leading to excessive fluid loss.