Despite their advantages, IGRAs have some limitations:
- Cost: IGRAs are generally more expensive than TST, which can be a barrier in resource-limited settings. - Technical Requirements: The tests require specialized laboratory equipment and trained personnel. - Indeterminate Results: In some cases, IGRAs can yield indeterminate results, particularly in immunocompromised individuals. - Not for Active TB: IGRAs cannot distinguish between latent and active TB infection, so additional diagnostic tests are required for active TB.
