Several risk factors contribute to the development and spread of MDR TB: 1. Previous TB Treatment: Inadequate or incomplete treatment of TB can lead to drug resistance. 2. HIV Co-infection: Individuals with HIV are more susceptible to TB and MDR TB due to their weakened immune systems. 3. Close Contact with MDR TB Patients: Household contacts and healthcare workers are at increased risk. 4. Socioeconomic Factors: Poor living conditions, lack of access to healthcare, and malnutrition can increase the risk.