1. Study Design: This involves selecting appropriate methodologies such as randomized controlled trials (RCTs), cohort studies, and case-control studies that can compare different interventions. 2. Data Sources: Utilizing a variety of data sources like clinical trials, observational studies, and electronic health records (EHRs) to gather comprehensive information. 3. Outcome Measures: Identifying relevant outcomes that matter to patients and healthcare providers, such as quality of life, mortality, and morbidity.