1. Observational Studies: These studies observe the outcomes of patients who choose alternative treatments in real-world settings. While they provide valuable insights, they can be prone to biases such as selection bias and confounding variables. 2. Randomized Controlled Trials (RCTs): Considered the gold standard in clinical research, RCTs randomly assign participants to either the treatment group or the control group to objectively measure the treatment’s effectiveness. 3. Meta-Analyses: These involve pooling data from multiple studies to derive more comprehensive conclusions about the effectiveness and safety of an alternative treatment.