What are the Challenges in Targeting the Hemagglutinin Stalk?
One of the main challenges in targeting the hemagglutinin stalk is its lower immunogenicity compared to the head region. The immune system naturally responds more robustly to the head, which can overshadow responses to the stalk. Researchers are working on various strategies to enhance the immune response to the stalk, including the use of adjuvants and novel vaccine delivery systems.