What are the Challenges in Pharmaceutical Substitution?
Despite its benefits, pharmaceutical substitution faces several challenges:
1. Bioequivalence: Ensuring that substituted drugs are bioequivalent to the original is essential for maintaining therapeutic efficacy and safety. 2. Patient Perception: Patients may perceive substituted drugs as inferior, affecting their confidence and adherence to treatment. 3. Regulatory Hurdles: Different countries have varying regulations regarding drug substitution. Harmonizing these regulations is critical for global public health. 4. Monitoring and Surveillance: Continuous monitoring and surveillance are required to detect any adverse effects or changes in health outcomes related to substitution.
