What Are the Challenges in HLA-Related Epidemiological Studies?
One of the main challenges in HLA-related epidemiological studies is the high degree of polymorphism in the HLA genes, which makes it difficult to analyze and interpret the data. Additionally, the interactions between HLA alleles and environmental factors are complex and not fully understood. These studies also require large sample sizes to achieve statistically significant results, which can be logistically and financially demanding.
