MDROs are bacteria and other microorganisms that have acquired resistance to several classes of antibiotics. This resistance can occur through various mechanisms such as mutation, horizontal gene transfer, and selective pressure from antibiotic use. Common examples include Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococci (VRE), and Carbapenem-resistant Enterobacteriaceae (CRE).