To ensure secure data sharing, several best practices should be followed. Data should be encrypted both in transit and at rest to prevent unauthorized access. Access controls, such as multi-factor authentication and role-based access, should be implemented to ensure that only authorized users can access sensitive data. Regular audits and monitoring of data access can help detect and prevent potential security breaches. Additionally, adopting frameworks like the Trusted Research Environment (TRE) can provide a secure infrastructure for data sharing.