Can Environmental Factors Influence Driver Mutations?
Yes, environmental factors such as exposure to carcinogens, radiation, and lifestyle choices (e.g., smoking, diet) can influence the occurrence of driver mutations. For example, tobacco smoke contains numerous carcinogens that can induce mutations in genes like TP53 and KRAS, contributing to lung cancer development. Similarly, UV radiation from sunlight can cause BRAF mutations, leading to melanoma. Epidemiological studies often investigate these associations to identify modifiable risk factors and inform public health interventions.
