There are several reasons why non-inferiority trials are employed: 1. Ethical Considerations: When a standard treatment exists, withholding it to test a placebo would be unethical. 2. Practicality: In some cases, the new treatment may offer other benefits, such as reduced side effects, cost, or improved administration. 3. Regulatory Requirements: Regulatory bodies often require non-inferiority trials to ensure that new treatments do not compromise patient care.
