1. Maintains Randomization: By analyzing participants in the groups to which they were originally assigned, ITT analysis preserves the balance achieved through randomization. This helps in providing an unbiased estimate of treatment effect. 2. Reflects Real-World Effectiveness: ITT analysis includes all participants, even those who did not adhere to the treatment protocol. This approach provides a more realistic measure of the intervention's effectiveness in real-world settings, where non-adherence is common. 3. Prevents Overestimation of Treatment Effect: By including non-compliant participants, ITT analysis prevents the overestimation of the treatment effect, which could occur if only adherent participants were considered.
