The CRM is particularly important in epidemiology for several reasons: 1. Adaptive Design: Unlike traditional methods, CRM uses an adaptive design, allowing researchers to make real-time adjustments based on current findings. This is crucial when dealing with emergent infectious diseases or in vaccine trials. 2. Efficiency: By focusing on the most informative dose levels, CRM can reduce the number of participants exposed to potentially harmful doses, thereby improving ethical standards. 3. Accuracy: CRM provides more accurate estimates of the optimal dose or exposure level compared to traditional fixed-dose designs.
