Understanding off-target effects is essential for several reasons: 1. Safety and Efficacy: Evaluating off-target effects ensures that interventions are both safe and effective for populations. 2. Risk-Benefit Analysis: It helps in weighing the benefits of an intervention against its potential risks. 3. Surveillance and Monitoring: Continuous monitoring of off-target effects can aid in early detection of adverse outcomes, allowing for timely intervention. 4. Policy and Regulation: Informing regulatory bodies about these effects can shape guidelines and recommendations for use.