Antibiotic prophylaxis is commonly used in several contexts: - Pre-surgical settings to prevent surgical site infections (SSIs). - Dental procedures for patients with certain heart conditions to prevent bacterial endocarditis. - Immunocompromised patients, such as those undergoing chemotherapy or organ transplants, to prevent opportunistic infections. - Exposure to specific pathogens, for example, after a needle-stick injury or close contact with someone with meningitis.