A cost-effective intervention offers significant health benefits relative to its costs. The main criterion is the cost-effectiveness ratio, which compares the cost of an intervention to the health outcomes it generates, typically measured in Quality-Adjusted Life Years (QALYs) or Disability-Adjusted Life Years (DALYs). An intervention is considered cost-effective if its cost per QALY or DALY is below a certain threshold, which varies by country and economic context.