Very low-density lipoprotein (VLDL) is a type of lipoprotein made by the liver. It is one of the five major groups of lipoproteins, which also include chylomicrons, low-density lipoprotein (LDL), intermediate-density lipoprotein (IDL), and high-density lipoprotein (HDL). VLDL is responsible for transporting triglycerides from the liver to various tissues in the body. Elevated levels of VLDL can be a risk factor for cardiovascular diseases.