The WHI is a comprehensive program consisting of a set of clinical trials and an observational study. These components were designed to address major health issues causing morbidity and mortality in postmenopausal women. The clinical trials focused on evaluating the effects of hormone replacement therapy (HRT), dietary modification, and calcium/vitamin D supplementation on health outcomes. The observational study aimed to identify predictors of disease outcomes and health trends in a large cohort of women over time.
