What is the Role of Helper T Cells in Chronic Infections?

In chronic infections, such as HIV and tuberculosis, the role of helper T cells becomes even more critical. HIV targets and depletes CD4+ T cells, leading to immunodeficiency and increased susceptibility to opportunistic infections. In tuberculosis, helper T cells are crucial for containing the infection and preventing its reactivation. Understanding the dynamics of helper T cell responses in these infections can aid in developing therapeutic strategies and public health interventions.