The ERCC6 gene, also known as CSB (Cockayne Syndrome B), encodes a protein that is part of the NER pathway. This protein helps to repair DNA damage by removing a wide range of DNA lesions. The ERCC8 gene, known as CSA (Cockayne Syndrome A), works in conjunction with ERCC6. Together, these proteins form a complex that is essential for transcription-coupled repair, a sub-pathway of NER that specifically targets and repairs DNA damage in active genes.
