Epidemiology studies the distribution and determinants of health-related states or events in specified populations. In the context of TBE, epidemiologists examine factors like the prevalence, incidence, and geographical distribution of the disease. TBE is endemic in certain regions, with hotspots identified in forested areas of Central, Eastern, and Northern Europe, as well as parts of Russia and East Asia. The disease is seasonal, primarily occurring during the warmer months when ticks are most active.