HSV is highly prevalent worldwide. According to the World Health Organization (WHO), an estimated 3.7 billion people under the age of 50 have HSV-1, and around 491 million people aged 15â49 have HSV-2 globally. The prevalence of HSV-1 is higher in developing countries, while HSV-2 is more commonly reported in developed nations. Both types of HSV have significant public health implications due to their widespread nature and potential to cause recurrent infections.