Prostate Specific Antigen (PSA) is a protein produced by both normal and malignant cells of the prostate gland. PSA is primarily found in semen, but small amounts can be detected in the blood. It is commonly used as a biomarker in the screening and monitoring of prostate cancer. Elevated levels of PSA in the blood can indicate the presence of prostate cancer, benign prostatic hyperplasia, or inflammation of the prostate.