Several factors influence disease pathogenesis, including the virulence of the pathogen, the immune status of the host, and environmental conditions. Virulence factors, such as toxins, enzymes, and adhesion molecules, enhance the pathogen's ability to cause disease. The host's immune response can either control the infection or contribute to disease severity through inflammation and tissue damage. Environmental factors, such as hygiene, climate, and vector presence, also play a significant role in the transmission and severity of diseases.