What Challenges Exist in Treating Gram-Negative Infections?
One of the significant challenges in treating gram-negative infections is antibiotic resistance. The outer membrane of these bacteria acts as a barrier to many antibiotics. Additionally, gram-negative bacteria can produce beta-lactamases, enzymes that break down beta-lactam antibiotics. The rise of multidrug-resistant strains, such as carbapenem-resistant Enterobacteriaceae (CRE), further complicates treatment options.
