Despite its successes, PEPFAR faces several challenges:
1. Sustainability: Ensuring the long-term sustainability of HIV/AIDS programs requires continuous funding, political commitment, and local ownership.
2. Drug Resistance: The emergence of drug-resistant HIV strains poses a threat to treatment efficacy and requires ongoing surveillance and development of new therapies.
3. Integration with Other Health Services: Integrating HIV services with other health services, such as tuberculosis (TB) and reproductive health, is essential for comprehensive care but can be challenging to implement.
