1. Funding: Securing sufficient and continuous funding can be difficult, especially in a competitive environment. 2. Ethical Issues: Navigating complex ethical dilemmas and ensuring compliance with ethical standards can be challenging. 3. Data Quality: Ensuring high-quality and reliable data collection is critical and can be difficult to maintain. 4. Interdisciplinary Collaboration: Epidemiological research often requires collaboration across various disciplines, which can pose coordination challenges. 5. Regulatory Compliance: Adhering to a multitude of regulatory requirements and guidelines can be a time-consuming and complex process.