What are the Limitations of Seroprevalence Studies?
While seroprevalence studies are powerful tools, they come with certain limitations:
Sampling Bias: The representativeness of the sample is crucial. Non-random sampling can lead to inaccurate estimates. Antibody Persistence: The duration for which antibodies remain detectable varies among individuals and diseases, affecting the accuracy of seroprevalence as a measure of past infection. Cross-Reactivity: Some antibodies may react to multiple pathogens, leading to false-positive results. Temporal Changes: Seroprevalence can change over time, necessitating repeated surveys for accurate monitoring.
