Despite their widespread use, QALYs have several limitations:
1. Subjectivity: The quality of life scores are subjective and can vary depending on individual preferences, cultural differences, and the method used to obtain them. 2. Equity Concerns: QALYs may inadvertently prioritize interventions that benefit younger, healthier individuals over those that benefit older or more severely ill patients. 3. Simplification: The single index nature of QALYs may oversimplify complex health states and ignore other important factors such as caregiver burden or social impact.
